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RESEARCH SCIENTISTS
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Dr.
Ganesh Babu |
ganesh_babu@bti.a-star.edu.sg
Research Scientist
Immunology Group
PhD in Biotechnology (2007), Alagappa University, India
Research Focus/ Interests:
MicroRNA in Immune cell development and function |
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Dr. Andrea
Camattari |
camattari_andrea@bti.a-star.edu.sg
Research Scientist
Microbial Cells Group
PhD in Industrial
Biotechnology (2006) University of Milano-Bicocca, Milan, Italy
Research Focus/ Interests:
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Expression of recombinant
proteins in yeast (Pichia pastoris) and bacteria.
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Elucidation
of transcriptional regulation in yeast (Pichia pastoris) and its
application in
protein
production.
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Dr. Ken
Chan |
ken_chan@bti.a-star.edu.sg
Research Scientist
Stem Cells Group
PhD in
Biochemistry
(1998) The
Chinese University of Hong Kong, Hong Kong
Research Focus/ Interests:
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Molecular and cellular
mechanisms of pluripotent stem cell
maintenance.
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Downstream signaling and
gene regulation of human embryonic stem (hES)
cells.
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Development of methods and
devices to scale up therapeutic quantities of
hES cells.
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Dr.
Jimmy Chao Sheng-Hao |
jimmy_chao@bti.a-star.edu.sg
Research Scientist
Expression Engineering Group
PhD in Molecular Biology
(2001)
University of Iowa, USA
Research Focus/ Interests:
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Protein
secretion and unfolded protein response.
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Regulation of
cellular and viral transcription.
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Dr.
Allen Chen |
allen_chen@bti.a-star.edu.sg
Research Scientist
Animal Cells
Group
PhD in
Biotechnology (2006) University of
New South Wales, Australia
Research Focus/ Interests:
The main
focus of my research is the bioprocess development for
influenza vaccine production using Vero cells. Other areas
of interest include growth study of human embryonic stem
cells using imaging technology and antibody production in
hybridomas.
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Dr.
Cheong Nge |
cheong_nge@bti.a-star.edu.sg
Senior Scientist
Expression Engineering Group
PhD in Zoology (1986)
Benaras Hindu University, India
Research Focus/ Interests:
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Molecular biology
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Regulation and mechanism of
transcription
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Dr. Andre Choo | andre_choo@bti.a-star.edu.sg
Senior Scientist
Stem Cells Group
PhD in
Biological
Science (2002) University of Technology, Sydney, Australia
Research Focus/ Interests:
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Development
of serum-free and feeder-free culture platforms for human
embryonic stem cells (hESC).
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Characterization of novel antibodies targeting hESC surface
antigens.
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Investigating the factors in the secretome of mesenchymal
stem cells which protects against ischemia/reperfusion
injuries.
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Dr.
Feng Huatao |
feng_huatao@bti.a-star.edu.sg
Research
Scientist
Analytics Group
PhD in
Analytical Chemistry (2004) National
University of
Singapore, Singapore
Research Focus/ Interests:
My research focuses on the
development of quantitative methods for monosaccharides,
sugar-nucleotides and nucleotides in metabolites. Another area
of interest is the effects of monolithic structures and nano-particles
to the performance of chromatography technologies.
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Dr. Hia Hui Ching |
hia_hui_ching@bti.a-star.edu.sg
Research
Scientist
Process Development Group
PhD in
Environmental Engineering
(2004)
Osaka University,
Japan
Research Focus/ Interests:
Development of
generic fed-batch feeding strategy for recombinant protein
production by mammalian cell culture, and
investigation of
scale-up of
the process for industrial production.
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Dr.
Ho Ying Swan
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ho_ying_swan@bti.a-star.edu.sg
Research Fellow
Analytics Group
PhD
in Chemical
Engineering (2007) Imperial
College, UK
Research Focus/ Interests:
Metabolic profiling/metabolomics
studies of mammalian cell lines to further understanding of
intracellular metabolic processes and their impact on
recombinant protein production.
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Dr.
Huo Jianxin
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huo_jianxin@bti.a-star.edu.sg
Research
Scientist
Immunology
Group
PhD
(2003), National University of Singapore, Singapore
Research Focus/ Interests:
- Cell cycle and apoptosis
signaling.
- Biological mechanism of
antitumor and immunosuppressant drugs.
- Mechanism of fulminant liver
failure
- Thymocyte development
- Islet biology
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Dr.
Kim Do Yun
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kim_do_yun@bti.a-star.edu.sg
Research Scientist
Animal Cells
Group
PhD in
Chemical & Biomolecular Engineering (2006) KAIST, Korea
Research Focus/ Interests:
- Process development:
optimization of culture media and scale-down models.
- Development of kinetic
models for fed-batch culture process.
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Dr.
Geoffrey Koh
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geoffrey_koh@bti.a-star.edu.sg
Research Fellow
Bioinformatics Group
PhD in Bioinformatics (2008) National
University of Singapore, Singapore
Research Focus/ Interests:
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Bio-pathway modeling, validation and analysis.
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Application of machine learning techniques in various areas
of biology.
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Development of tools for machine learning and analysis.
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Dr.
Louise Lai
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louise_lai@bti.a-star.edu.sg
Research
Scientist
Immunology
Group
PhD
(2010) National University of Singapore, Singapore
Research Focus/ Interests:
- TLR signaling
- B cell development
- Autoimmunity
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Dr.
Lam Kong Peng
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lam_kong_peng@bti.a-star.edu.sg
Scientific Director
Head, Immunology Group
PhD in
Microbiology (1994),
Columbia University, USA
Research Focus/ Interests:
- Immunology.
- Infectious Diseases and
Autoimmunity.
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Dr.
Marti Lecina
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marti_lecina@bti.a-star.edu.sg
Research Scientist
Stem Cells Group
PhD in
Chemical Engineering (2007),
University Autonomous of Barcelona, Spain
Research Focus/ Interests:
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Development of a platform to scale-up Human Embryonic Stem
Cells on microcarriers cultures.
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Characterization of hESC cultures in bioreactors.
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Studying differentiation processes of hESC.
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Dr. Lee
Dong-Yup
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lee_dong_yup@bti.a-star.edu.sg
Research Scientist
Bioinformatics Group
PhD in Chemical &
Biomolecular
Engineering (2004) KAIST,
Korea
Research Focus/ Interests:
- Computational Analysis and
Engineering
of Biological Systems.
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Bioinformatics Analysis of Omics Data.
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Bioinformatics Platform and Tool Development.
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Dr.
Lee Yih Yean
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lee_yih_yean@bti.a-star.edu.sg
Research Scientist
Animal Cells
Group
PhD
in Chemical
Engineering (2006) National
University of Singapore, Singapore
Research Focus/ Interests:
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Development
of proprietary protein-free, chemically defined media for
cell lines.
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Cellular
engineering to improve recombinant protein production.
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Dr.
Li Bin
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li_bin@bti.a-star.edu.sg
Research Scientist
Proteomics
Group
PhD
in Pharmaceutical Analysis (2005) Chinese Academy of Medical
Sciences and
Peking Union Medical
College, China
Research Focus/ Interests:
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Mass spectrometry method
development and the related application in proteomics,
including posttranslational modifications, quantification
technologies, etc.
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Novel mass spectrometric assays
for the bioanalysis of recombinant proteins as well as
protein drugs.
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Dr. Bernard Loo
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bernard_loo@bti.a-star.edu.sg
Research Fellow
Animal Cells
Group
PhD in
Chemical Engineering (2007), Georgia Institute of Technology,
USA
Research Focus/ Interests:
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Engineering
cell culture by utilizing genomic and microarray information.
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Metabolic
engineering.
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Dr.
Meng Lei
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meng_lei@bti.a-star.edu.sg
Research
Scientist
Immunology
Group
PhD in
(2008) Nanyang
Technological University, Singapore
Research Focus/ Interests:
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Protein-protein interactions in signaling
transduction of immune system
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Dr.
Monika Mueller
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monika_mueller@bti.a-star.edu.sg
Research Scientist
Downstream Processing
Group
PhD in Biotechnology (2008) University of Natural Resources and
Applied Life Sciences, Vienna,
Austria
Research Focus/ Interests
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Current
research focus is on antibody purification. Other area of
interest is binding and activation studies of human hormone
receptors and cell culture models.
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Dr. Ng Say Kong
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ng_say_kong@bti.a-star.edu.sg
Research Scientist
Animal Cells
Group
PhD in
Molecular Engineering of
Biological and Chemical Systems (2006) National
University of Singapore, Singapore
Research Focus/ Interests:
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Optimization
of recombinant protein expression in mammalian cells.
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Production
of viral vaccines using mammalian cells.
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Dr. Valerie Ng
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valerie_ng@bti.a-star.edu.sg
Research Scientist
Stem Cells
Group
PhD in Pharmaceutical Chemistry (2005) University of
California, San Francisco, USA
Research Focus/ Interests:
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To
understand molecular mechanisms involved in the maintenance of
pluripotent human embryonic stem
cells
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To
characterize novel stem cell-specific monoclonal antibodies and
their mechanism of action
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Dr. Peter Nissom | peter_morin@bti.a-star.edu.sg
Research Scientist
Microarray Laboratory
PhD in Molecular Biology (1998) University of Oxford, UK
Research Focus/ Interests:
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Development
of CHO chip
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Expression
profiling of CHO to enhance recombinant protein
productivity
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Dr. Steve Oh | steve_oh@bti.a-star.edu.sg
Principal Scientist
Stem Cells Group
PhD in Chemical Engineering (1991) University of Birmingham, UK
Research Focus/ Interests:
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Imaging of
stem cells in 2-D and 3-D.
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Establishing
methods to scale-up and differentiate hESC in microcarrier
cultures.
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Dr.
Ou Xijun
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ou_xijun@bti.a-star.edu.sg
Research Scientist
Immunology Group
PhD in
Microbiology (2009), Fudan University, China
Research Focus/ Interests:
Signal transduction through immune
receptors
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Dr.
Dave Ow
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dave_ow@bti.a-star.edu.sg
Research Fellow
Microbial Cells Group
PhD (2007)
National University of
Singapore, Singapore
Research Focus/ Interests:
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Elucidation of metabolic
networks using a system-level “omics” approach
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Metabolic engineering
emphasizing on the global regulatory network to develop
industrially-relevant improved microbial strains.
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Fermentation process development
for periplasmic antibody fragment production in E. coli.
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Dr. Gernalia
Satianegara |
gernalia_satianegara@bti.a-star.edu.sg
Research
Scientist
Animal Cells Group
PhD in Biotechnology (2006)
University of New South Wales, Australia
Research Focus/ Interests:
Current
research focus is on large scale antibody production in
hybridoma cultures. Another area of interest is cell adaptation
to protein-free chemically defined media for an industrial
feasible process.
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Dr.
Kornelia Schriebl |
kornelia_schriebl@bti.a-star.edu.sg
Research
Scientist
Downstream Processing Group
PhD in
Biotechnology (2006) University of Natural Resources and Applied
Life Sciences, Austria
Research Focus/ Interests:
The current research focus is on
purification of embryonic stem cells. Another area of interest
is the glycosylation analysis.
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Dr.
Suresh Selvarasu |
suresh_selvarasu@bti.a-star.edu.sg
Research
Scientist
Bioinformatics Group
PhD in
Chemical & Biomolecular Engineering (2009),
National University of Singapore, Singapore
Research Focus/ Interests:
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Modeling and analysis of microbial and mammalian
metabolic networks
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Application of optimization techniques for strain
improvement
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Analysis of gene regulatory networks
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Dr.
Song Zhiwei |
song_zhiwei@bti.a-star.edu.sg
Senior Scientist
Expression Engineering Group
PhD in
Biochemistry (1993)
University of Michigan, Ann Arbor, USA
Research Focus/ Interests:
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Protein
glycosylation
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Apoptosis
in cultured mammalian cells
- Developing IgG-like fusion
proteins as potential drugs.
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Dr. Danny
Wong |
danny_wong@bti.a-star.edu.sg
Research Scientist
Animal Cells
Group
PhD (2006) National
University of Singapore, Singapore
Research Focus/ Interests:
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Mammalian Cell Line Engineering with Emphasis on Improving
Recombinant Protein Productivity,
Yield and Quality.
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Apoptosis Signaling Pathways in Cell Culture Processes
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Dr. Niki Wong
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niki_wong@bti.a-star.edu.sg
Research Scientist
Animal Cells Group
PhD in Molecular Engineering of Biological and Chemical Systems
(2005), SMA National
University of Singapore,
Singapore
Research Focus/ Interests:
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Intracellular
profiling of N-glycosylation in cell culture
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Cellular
engineering to improve glycosylation
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Dr. Victor Wong |
victor_wong@bti.a-star.edu.sg
Research Scientist
Microbial Cells
Group
PhD in Chemical Engineering (2001) University of Adelaide,
Australia
Research Focus/ Interests:
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High-throughput expression of
antibody fragments and recombinant fusion proteins in
microbial systems
- Development of C-type lectin
fusion proteins
- Protein-free media
development for mammalian cell cultures and transcriptional
analysis of culture media effects
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Dr.
Xu Shengli
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xu_shengli@bti.a-star.edu.sg
Research Scientist
Immunology Group
PhD
in Immunology
(2003) National University of Singapore, Singapore
Research Focus/ Interests:
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Regulation of B lymphocyte differentiation.
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Signal
transduction through immune receptors
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Dr. Yang Yuansheng
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yang_yuansheng@bti.a-star.edu.sg
Research Scientist
Animal Cells Group
PhD in Chemical Engineering (2005)
Vanderbilt University,
USA
Research Focus/ Interests:
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Investigation
of metabolism of mammalian cells genetically engineered to produce therapeutic proteins and monoclonal antibodies.
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Development
and application of high throughput assays for medium design and
cell line selection.
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Online
monitoring of bioprocess.
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